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radical but certain; one dose of tar and feathers or riding on a rail would be sure to stop all further non- sense. DR. EDSON'S ASEPTOLIN A CRITICISM. To the Editor of the Medical Record. Sir: It low cost viagra is quite probable that we are on the eve of discovering or inventing a cure for tuberculosis which shall be entirely rational and at least as successful as the antitoxin treatment of diphtheria. For this reason the reports of all original investigation into the therapeutics of tuberculosis are eagerly read and closely criticised. Dr. Cyrus Edson's article in the Medical Record for February 8th will undoubtedly excite a good deal of interest and bring forth some unfavorable criticism. In the first place Dr. Edson has not allowed a suffi- ciently long period of time to elapse to justify his pronouncing a single case cured. In the history of the first case he gives, treatment was begun on the 3d of September last. I am aware that he discusses conditions which might make the cure low cost viagra apparent, while as a matter of fact the disease is only in a quiescent state; but in summing up his two hundred and six- teen cases he says that " twenty-three have been dis- charged cured." Certainly two and perhaps five years should elapse after every vestige of the disease has disappeared before a verdict can be pronounced. In the beginning of his article the doctor has drawn some conclusions which are unwarranted by the evi- dence. Speaking of the production of phenol within a body suffering from bacterial invasion, he says: "The increased secretion of phenol by the system during citalopram and viagra the disease is, in fact, one of nature's many devices to cure the underlying condition, to destrov the germ infection." Now, there is not one scrap of evidence to show that a sufficient quantity of phenol has been produced within a diseased body to destroy the parasites producing the disease. The implication here is very strong that a germ disease ceases when the body has produced sufficient phenol to destroy the germ or inhibit citalopram and viagra its growth. Buchner, however, found (Gunther's " Bakteriologie," S. 185) that during citalopram and viagra the course of a self-limited bacterial disease a certain al- buminous body is produced which destroys the dis- ease germ. He found that this substance was in so- lution in the blood serum, that it could be removed by dialysis in the presence of water, and that it de- stroyed the same bacterium that produced the disease in an artificial culture medium. Indeed, the efficacy of the serum therapy depends entirely upon the pro- duction of these albuminous substances. It is well known, too, that an attack of a self-limited bacterial disease confers immunity upon the subject attacked. Sometimes this immunity is perpetual and sometimes it low cost viagra lasts for only a few months. If the phenol were 354 MEDICAL RECORD. [March 7, low cost viagra 1896 the agent effecting the cure, it low cost viagra would produce no im- munity, for it is not cumulative; on the other hand, it is very diffusible and is eliminated within twenty- four hours (Bartholow's " Therapeutics"). "This reasoning," says low cost viagra Dr. Edson, " naturally led me to think that phenol was selected by nature for the cure of some, if not all, of the so-called germ dis- eases. Of course the conclusion was obvious, low cost viagra but the corollary of that conclusion, which assumed a great importance in my mind, was this: If nature herself provides phenol during disease, then it cannot be possible that she will not tolerate the administration of the agent in effective dosage." (!) These are certainly amazing statements to be made with that deliberation which should characterize the language of a thought- ful scientific investigator. It is difficult to conceive of reasoning more inane or childish than this. Sugar is a useful article produced by the diseased condition known as diabetes mellitus; but that does not signify even the remote possibility of sugar being a useful agent in the treatment of diabetes. The amount of uric acid excreted is increased in all bacterial dis- eases attended by low cost viagra citalopram and viagra an elevation of the low cost viagra temperature, but this fact certainly has no therapeutic significance. Furthermore, it is as firmly established as any fact can be established by experiment that the citalopram and viagra internal administration of no germicide is efficient in the cure of disease unless it can be given in quantity sufficient to make a solution of the circulating fluids of the body strong enough to prevent the growth of or to destroy the parasite outside of the body. The fluid used by Dr. Edson, injected hypodermatically, contains not quite n per cent, of phenol. Of this solution he administers from 70 to 120 minims per day from 1. 91 gr. to 3.30 gr. Now, a man weighing, say, 130 pounds would have circulating fluids to the total amount of 10 pounds or 70,000 grains avoidupois, estimating the fluids at one-thirteenth of the total weight of the body, which anatomists have found to be